Fri May 13 2022

29 articles - From Friday May 06 2022 to Friday May 13 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Arthritis Res Ther

Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis.

PUFA consumption, especially omega-3 from animal source >2 g/day, may improve IRD activity and might be an adjuvant therapy in rheumatoid arthritis.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Rheum Dis

Krüppel-like factor-4 and Krüppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis.

KLF4 and KLF2 may be central transcription factors that increase protective and regenerative functions in joint tissue cells, suggesting that KLF gene transfer or molecules upregulating KLFs are therapeutic candidates for OA.

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Arthritis Res Ther

Apolipoprotein C-III in patients with systemic lupus erythematosus.

Among SLE patients, disease activity, severity, and disease damage are independently associated with higher ApoC3 serum levels.

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Gastric antral vascular ectasia in systemic sclerosis: a study of its epidemiology, disease characteristics and impact on survival.

GAVE is an underestimated and underappreciated SSc manifestation of SSc, which occurs with a relatively high frequency. Identifying an at-risk GAVE phenotype, as presented herein, is of practical importance as screening may prove advantageous given GAVE can be easily diagnosed and treated.

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Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren's syndrome.

Our data indicates that Tregs have a weakened immunosuppressive function in patients with SS due to impaired IL-2/IL-2R signalling capacity. This could mediate lymphocytic infiltration into salivary glands inducing sicca symptoms. We believe that sIL-2R could act as a useful indicator for SS and disease severity.

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Risk factors and surgical prognosis in patients with aortic valve involvement caused by Takayasu arteritis.

Regularly echocardiogram screening is suggested in patients with Numano type IIb and aggressive treatment should be performed early in TAK patients. As for TAK patients with aortic valve surgery, aortic root replacement seems to be the preferred option and regular anti-inflammatory therapy may reduce the occurrence of adverse events of them.

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Arthritis Rheumatol

Evaluation of Serum Urate Levels and the Clinical Manifestation of Gout with Cardiovascular Mortality from the CARES Trial.

In CARES, febuxostat and allopurinol (=600 mg doses) had comparable efficacy in patients with gout and cardiovascular disease, with no relationships between cardiovascular mortality and sUA, gout flares, or tophus resolution with febuxostat.

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Rheumatology (Oxford)

Anatomical variation of the sacroiliac joint carries an increased risk for erosion and bone marrow oedema in axial spondyloarthritis.

Joint form variations are associated with the presence of inflammatory lesions on SI joint MRI of axSpA patients. This should be taken into consideration in future research on the interplay of mechanical strain and inflammation in axSpA.

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Anti-citrullinated protein antibody specificities and pulmonary fibrosis in relation to genetic loci in early rheumatoid arthritis.

The development of PF in an inception cohort of RA patients was associated with both presence of certain ACPA, and the number of ACPA specificities and risk genes.

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Identification and functional characterization of imbalanced osteoarthritis associated fibronectin splice variants.

We show that full length FN1 downregulation and concomitant relative FN1-208 upregulation was unbeneficial for deposition of cartilage matrix, likely due to decreased availability of the classical RGD integrin-binding site of fibronectin.

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Musculoskeletal ultrasound for treating rheumatoid arthritis to target-a systematic literature review.

Higher ultrasound scores of synovitis were linked to poor outcomes at al disease stages, however, a specific cut-off distinguishing between low- and high-risk groups did not emerge. These data confirm the pivotal role of ultrasound when evaluating synovial inflammation and when identifying RA patients at higher risk of relapse. Further research is needed to better define the role of ultrasound in a T2T management strategy in moderately-to-highly active RA.

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Panel sequencing links rare, likely damaging gene variants with distinct clinical phenotypes and outcomes in juvenile-onset SLE.

Approximately 3.5% of jSLE patients present damaging gene variants associated with younger age at onset, and distinct clinical features. As less commonly observed after treatment induction, in "genetic" SLE, autoantibody positivity may be the result of tissue damage and explain reduced immune complex-mediated renal and haematological involvement. Routine sequencing could allow for patient stratification, risk assessment, and target-directed treatment, thereby increasing efficacy and reducing toxicity.

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Reclassification of previously diagnosed GPA patients using the 2022 ACR/EULAR classification criteria.

Among the 17 patients unclassified as having GPA, 16 patients were reclassified as having MPA and one as having unclassifiable vasculitis, and furthermore, 94.1% of them harboured myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA) (or perinuclear (P)-ANCA). The concordance rate between the 2022 ACR/EULAR criteria for GPA and the previous criteria in patients with previously diagnosed GPA was 73.8%. Although the 2022 ACR/EULAR criteria are the product of the most advanced methodologic process, it should be noted that there were some consequences of distorting the CHCC definition, and further discussion is required, especially with respect to the weightage of the items.

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Thigh MRI in antisynthetase syndrome, and comparisons with dermatomyositis and immune-mediated necrotising myopathy.

Thigh MRI in ASS exhibited frequent myofascial oedema. ASS oedema patterns resembled those of DM more than those of IMNM. Bilateral asymmetry, adductor-muscle relative sparing and remarkable myofascial oedema of tensor fasciae latae were the most characteristic ASS imaging findings.

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Thrombocytopenia in primary antiphospholipid syndrome: Association with prognosis and clinical implications.

Thrombocytopenia could identify primary APS patients at high risk of developing thrombotic events, pregnancy morbidity and severe extra-criteria events.

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Ultrasound and MR muscle imaging in new onset idiopathic inflammatory myopathies at diagnosis and after treatment: a comparative pilot study.

At diagnosis, MRI was more sensitive than US to detect muscle abnormalities compatible with IIM. Semi-quantitative US and qualitative US detected abnormalities in the majority of the patients while evaluating fewer muscles than MRI and showed change over time after nine weeks of treatment.

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Worse outcomes linked to ethnicity for early inflammatory arthritis in England and Wales: a national cohort study.

We demonstrate that some ethnic minorities are less likely to achieve disease remission in three months following EIA diagnosis. This is not explained by delays in referral or time to treatment. Our data highlight the need for investigation into the possible drivers of these inequitable outcomes and reappraisal of EIA management pathways.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Arthritis Res Ther

Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence.

Since the underlying mechanisms of OA onset and progression have not been fully elucidated yet, the development of novel therapeutics to prevent, halt, or reverse the disease is laborious. Recently, small molecules of herbal origin have been reported to show potent anti-inflammatory, anti-catabolic, and anabolic effects, implying their potential for treatment of OA. Herein, the molecular mechanisms of these small molecules, their effect on physiological or pathological signaling pathways, the advancement of the extraction methods, and their potential clinical translation based on in vitro and in vivo evidence are comprehensively reviewed.

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Arthritis Rheumatol

Towards precision medicine - is genetic risk prediction ready for prime time in osteoarthritis?

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Letters&Replies

Letters to the editors and authors’ replies

Arthritis Rheumatol

Criteria for the pathogenicity of anticentromere (anti-CENP-B) autoantibodies in systemic sclerosis: Comment on the article of van Leeuwen et al.

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Others

all remaining publications eg case reports, images of the month, etc…

Ann Rheum Dis

Sequential interleukin-17/interleukin-23 inhibition in treatment-refractory psoriatic arthritis.

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Arthritis Rheumatol

The Transition from Residency to Fellowship: Enhancing Training by Increasing Transparency.

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Rheumatology (Oxford)

A giant coronary artery aneurysm in a patient with Behçet's syndrome.

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Comment on 'Muscle involvement in systemic lupus erythematosus: multimodal ultrasound assessment and relationship with physical performance': reply.

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Comment on: Muscle involvement in systemic lupus erythematosus: multimodal ultrasound assessment and relationship with physical performance.

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Immune transcriptome and antibody response in adult-onset Still's disease with mild flare following administration of mRNA vaccine BNT162b2.

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Increased erythrocyte mean corpuscular volume by methotrexate predicts clinical response in psoriatic arthritis.

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Registry based studies on pregnancy and rheumatic diseases: generating actionable evidence.

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The role of PET/CT in the evaluation of patients with large-vessel vasculitis: useful for diagnosis but with potential limitations for follow-up.

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